Thymidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL002127
Members of this Pool
Members of control pools
POOL002125 POOL002126
Last modified: 10/Sep/2021
Results
Publication
Garone C, Garcia-Diaz B, Emmanuele V, Lopez LC, Tadesse S, Akman HO, Tanji K, Quinzii CM, Hirano M: Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency., EMBO Mol Med, 2014

PubMed PMCID
Value 0.15
Dimension pmol/mg protein
Error (standard deviation) 0.04
Data presentation in publication numerical
Source
Source organism mouse (Mus musculus)
Taxonomy 10090
Sample source tissue
Tissue type liver
Compartment mitochondrion
Experiment Details
Measurement type dNTP incorporation assay
Extraction method methanol
Growth conditions Mice were housed and bred according to international standard conditions, with a 12-h light, 12-h dark cycle, and sacrificed at 29 days of age; treated with dCMP+dTMP 200 mg/kg/day
Treatment
Genes and Proteins
Gene name Tk2
Gene identifier 57813
Protein name Thymidine kinase 2, mitochondrial
Protein identifier Q9R088
Genetic manipulation/variation mutation
Mutation in protein H126N (Tk2-/-)