DNTP008388
dATP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL002093 |
| Members of this Pool |
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| Members of control pools | |
|---|---|
| POOL002090 | POOL002091 |
|
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Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Badia R, Angulo G, Riveira-Muñoz E, Pujantell M, Puig T, Ramirez C, Torres-Torronteras J, Martí R, Pauls E, Clotet B, Ballana E, Esté JA: Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.,
J Antimicrob Chemother, 2016
PubMed PMCID |
| Value | 1.944 | Dimension | pmol/106 cell |
| Error (standard deviation) | 0.4131 |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
| Sample source | primary cells |
| Tissue type | monocyte-derived macrophages |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | acid extraction |
| Growth conditions | primary monocyte-derived macrophages (MDM) treated with palbociclib (4 μM) in the presence of Virus-like particle Vpx |
| Treatment | |
|---|---|
| Drug/stress type | drug + stress |
| Stress type | viruls-like particle Vpx treatment |
| PubChem | 5330286 |
| Applied drug | Palbociclib |
| Treatment details/effects | Vpx-induced degradation of SAMHD1; CDK4/6 inhibition by palbociclib |
| Genes and Proteins | |
|---|---|
| No genes or proteins manipulated. | |