DNTP008183
dTTP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL002041 |
| Members of this Pool |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Pauls E, Badia R, Torres-Torronteras J, Ruiz A, Permanyer M, Riveira-Muñoz E, Clotet B, Marti R, Ballana E, Esté JA: Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.,
AIDS, 2014
PubMed |
| Value | 2.28 | Dimension | pmol/106 cell |
| Error (standard deviation) | 0.75 |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
| Sample source | primary cells |
| Tissue type | monocyte-derived macrophages |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | acid extraction |
| Remarks to measurement type | Ferraro |
| Growth conditions | MDMs were pretreated with viral like proteins carrying vpx for 24 h |
| Treatment | |
|---|---|
| Drug/stress type | stress |
| Stress type | viruls-like particle Vpx treatment |
| Treatment details/effects | Vpx-induced degradation of SAMHD1 |
| Genes and Proteins | |
|---|---|
| No genes or proteins manipulated. | |