Results
Publication	Pontarin G, Ferraro P, Bee L, Reichard P, Bianchi V: Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells., Proc Natl Acad Sci U S A, 2012 PubMed PMCID
Value	0.12
Dimension	pmol/106 cell
Error	Error not provided.
Data presentation in publication	diagram

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Tissue type	fibroblasts
Cell line/type as in publication	p53R2 mutant fibroblast
Compartment	whole cell

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	modified Sherman and Fyfe; Ferraro
Growth conditions	Irradiation with UV (24 J/m2); 1/2h recovery; 2 mM HU

Treatment
Drug/stress type	drug + stress
Stress type	UV
PubChem	3657
Applied drug	hydroxyurea
Treatment details/effects	UV (DNA damage); ability to reduce ribonucleotides was strongly curtailed; RNR inhibition

Genes and Proteins
Gene name	RRM2B
Gene identifier	50484
Protein name	Ribonucleoside-diphosphate reductase subunit M2 B
Protein identifier	Q7LG56
Genetic manipulation/variation	mutation
Mutation in protein	homozygous missense mutation in the iron-binding center