Results
Publication	Pontarin G, Ferraro P, Bee L, Reichard P, Bianchi V: Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells., Proc Natl Acad Sci U S A, 2012 PubMed PMCID
Value	4.56
Dimension	pmol/106 cell
Error (standard error of the mean)	0.53
Data presentation in publication	diagram

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Tissue type	fibroblasts
Cell line/type as in publication	p53R2 mutant fibroblast
Compartment	whole cell

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	modified Sherman and Fyfe; Ferraro
Growth conditions	pretreated with 20-50 ng/ml EtBr then 2 wk recovery period, no NdR in medium

Treatment
Drug/stress type	drug
PubChem	14710
Applied drug	Ethidium bromide
Treatment details/effects	ability to reduce ribonucleotides was strongly curtailed; mtDNA depletion

Genes and Proteins
Gene name	RRM2B
Gene identifier	50484
Protein name	Ribonucleoside-diphosphate reductase subunit M2 B
Protein identifier	Q7LG56
Genetic manipulation/variation	mutation
Mutation in protein	homozygous missense mutation in the iron-binding center