Results
Publication	Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, Reichard P, Bianchi V: The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells., Proc Natl Acad Sci U S A, 2013 PubMed PMCID
Value	2.3
Dimension	pmol/106 cell
Error (standard error of the mean)	0.5
Data presentation in publication	numerical

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Tissue type	P53R2- skin fibroblasts
Cell line/type as in publication	skin fibroblast cell line derived from a patient with an inactivating mutation in RRM2B, the gene for p53r2
Compartment	whole cell

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	modified Sherman and Fyfe; Ferraro
Growth conditions	Quiescent cultures; 10 d of serum starvation

Treatment
Drug/stress type	stress
Stress type	starvation
Treatment details/effects	Starvation; SAMHD1 silencing; inactivating mutation in p53R2

Genes and Proteins
Gene name	SAMHD1
Gene identifier	25939
Protein name	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Protein identifier	Q9X3Z3
Genetic manipulation/variation	silencing
Gene name	RRM2B
Gene identifier	50484
Protein name	Ribonucleoside-diphosphate reductase subunit M2 B
Protein identifier	Q7LG56
Genetic manipulation/variation	mutation
Mutation in protein	inactivating mutation