Thymidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001776
Members of this Pool
Members of control pools
POOL001773
Last modified: 10/Sep/2021
Results
Publication
Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, Reichard P, Bianchi V: The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells., Proc Natl Acad Sci U S A, 2013

PubMed PMCID
Value 1.19
Dimension fold change
Error (standard error of the mean) 0.04
Relative compared to control
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source cell line
Tissue type lung fibroblasts
Cell line/type as in publication lung fibroblasts (CCD34Lu)
Compartment whole cell
Experiment Details
Measurement type dNTP incorporation assay
Extraction method methanol
Remarks to measurement type modified Sherman and Fyfe; Ferraro
Growth conditions Proliferating cultures transfected for 24 h with anti-SAMHD1 siRNAs
Treatment
Genes and Proteins
Gene name SAMHD1
Gene identifier 25939
Protein name Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Protein identifier Q9X3Z3
Genetic manipulation/variation silencing