Results
Publication	Xie M, Yen Y, Owonikoko TK, Ramalingam SS, Khuri FR, Curran WJ, Doetsch PW, Deng X: Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase., Cancer Res, 2014 PubMed PMCID
Value	0.27
Dimension	pmol/106 cell
Error (standard deviation)	0.13
Data presentation in publication	diagram

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Tissue type	lung
CLO Cell line name	NCI-H1299 cell (CLO:0007986)
Cell line/type as in publication	H1299
Compartment	whole cell

Experiment Details
Measurement type	HPLC-UV
Extraction method	acid extraction
Growth conditions	N/A

Treatment
Treatment details/effects	removal of the BH4 domain from Bcl2 eliminates its inhibitory effect on RNR activity

Genes and Proteins
Gene name	Bcl2
Gene identifier	12043
Protein name	Apoptosis regulator Bcl-2
Protein identifier	P10417
Genetic manipulation/variation	extrachromosomal expression of mutant protein
Mutation in protein	ΔBH4 (BH4 domain deleted)