2'-Deoxyguanosine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001709
Members of this Pool
Members of control pools
POOL001698 POOL001704
Last modified: 10/Sep/2021
Results
Publication
Chen G, Luo Y, Warncke K, Sun Y, Yu DS, Fu H, Behera M, Ramalingam SS, Doetsch PW, Duong DM, Lammers M, Curran WJ, Deng X: Acetylation regulates ribonucleotide reductase activity and cancer cell growth., Nat Commun, 2019

PubMed PMCID
Value 5.607
Dimension pmol/106 cell
Error (standard deviation) 0.141
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source cell line
Tissue type lung
CLO Cell line name NCI-H1299 cell (CLO:0007986)
Cell line/type as in publication H1299
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions RPMI 1640 medium, 10% FBS
Treatment
Treatment details/effects RRM2 silencing; mutated RRM2 overexpression
Genes and Proteins
Gene name RRM2
Gene identifier 6241
Protein name Ribonucleoside-diphosphate reductase subunit M2
Protein identifier P31350
Genetic manipulation/variation silencing
Gene name RRM2
Gene identifier 6241
Protein name Ribonucleoside-diphosphate reductase subunit M2
Protein identifier P31350
Genetic manipulation/variation extrachromosomal expression of mutant protein
Mutation in protein K283Q