DNTP005883
dGTP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL001470 |
| Members of this Pool |
|
| Members of control pools |
|---|
| POOL001467 |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC: Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.,
Cancer Cell, 2015
PubMed PMCID |
| Value | 5.8824 | Dimension | pmol/106 cell |
| Error (standard error of the mean) | 1.9853 |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
| Sample source | cell line |
| Tissue type | human osteosarcoma |
| CLO Cell line name | U-2 OS cell (CLO:0009454) |
| Cell line/type as in publication | U-2 OS |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | methanol |
| Remarks to measurement type | Sherman and Fyfe |
| Growth conditions | Transfection for 72 h, then treatment for 24 h with LY2603618 (500 nM) |
| Treatment | |
|---|---|
| Drug/stress type | drug |
| PubChem | 11955855 |
| Applied drug | LY2603618 |
| Treatment details/effects | LY2603618, a CHK1 inhibitor |
| Genes and Proteins | |
|---|---|
| Gene name | SETD2 |
| Gene identifier | 29072 |
| Protein name | Histone-lysine N-methyltransferase SETD2 |
| Protein identifier | Q9BYW2 |
| Genetic manipulation/variation | silencing |