Thymidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001452
Members of this Pool
Members of control pools
POOL001451
Last modified: 10/Sep/2021
Results
Publication
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA: Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells., J Biol Chem, 2019

PubMed PMCID
Value 0.6187
Dimension fold change
Error (standard deviation) 1.44
Relative compared to control
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source primary cells
Cell line/type as in publication human mammary epithelial cells (HMECs)
Compartment whole cell
Experiment Details
Measurement type LC-MS
Extraction method methanol
Growth conditions cells at ~8 population doublings were treated with 2 μM triapine for 72 h (control cells were treated with DMSO)
Treatment
Drug/stress type drug
PubChem 9571836
Applied drug triapine
Treatment details/effects cells were treaed with triapine, an inhibitor of ribonucleoside-diphosphate reductase
Genes and Proteins
No genes or proteins manipulated.