DNTP005789
dTTP
dNTP Pool | |
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Pool identifier | POOL001452 |
Members of this Pool |
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Members of control pools |
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POOL001451 |
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Last modified: 10/Sep/2021
Results | |
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Publication |
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA: Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.,
J Biol Chem, 2019
PubMed PMCID |
Value | 0.6187 | Dimension | fold change |
Error (standard deviation) | 1.44 |
Relative compared to | control |
Data presentation in publication | diagram |
Source | |
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Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
Sample source | primary cells |
Cell line/type as in publication | human mammary epithelial cells (HMECs) |
Compartment | whole cell |
Experiment Details | |
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Measurement type | LC-MS |
Extraction method | methanol |
Growth conditions | cells at ~8 population doublings were treated with 2 μM triapine for 72 h (control cells were treated with DMSO) |
Treatment | |
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Drug/stress type | drug |
PubChem | 9571836 |
Applied drug | triapine |
Treatment details/effects | cells were treaed with triapine, an inhibitor of ribonucleoside-diphosphate reductase |
Genes and Proteins | |
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No genes or proteins manipulated. | |