2'-Deoxycytidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001452
Members of this Pool
Members of control pools
POOL001451
Last modified: 10/Sep/2021
Results
Publication
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA: Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells., J Biol Chem, 2019

PubMed PMCID
Value 0
Dimension fold change
Error (standard deviation) 4.32
Relative compared to control
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source primary cells
Cell line/type as in publication human mammary epithelial cells (HMECs)
Compartment whole cell
Experiment Details
Measurement type LC-MS
Extraction method methanol
Growth conditions cells at ~8 population doublings were treated with 2 μM triapine for 72 h (control cells were treated with DMSO)
Treatment
Drug/stress type drug
PubChem 9571836
Applied drug triapine
Treatment details/effects cells were treaed with triapine, an inhibitor of ribonucleoside-diphosphate reductase
Genes and Proteins
No genes or proteins manipulated.