2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001289
Members of this Pool
Members of control pools
POOL001284
Last modified: 10/Sep/2021
Results
Publication
Elstein KH, Mole ML, Setzer RW, Zucker RM, Kavlock RJ, Rogers JM, Lau C: Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells., Toxicol Appl Pharmacol, 1997

PubMed
Value 22
Dimension pmol/106 cell
Error (95 % confidence interval) 18; 26
Data presentation in publication numerical
Source
Source organism mouse (Mus musculus)
Taxonomy 10090
Sample source cell line
CLO Cell line name MELC cell (CLO:0007672)
Cell line/type as in publication murine erythroleukemic cell (MELC)
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions 2 hours exposure of asynchronous MELC to 10 μM 5-FU afterwards 1 mM 2'-Deoxycytidine treatment for 2 hours
Treatment
Drug/stress type drug
PubChem 3385 , 13711
Applied drug 5-Fluorouracil, 2'-Deoxycytidine
Treatment details/effects Thymidylate synthase inhibition and deoxycytidine nucleoside supplementation
Genes and Proteins
No genes or proteins manipulated.