DNTP004969
dTTP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL001262 |
| Members of this Pool |
|
| Members of control pools |
|---|
| POOL001259 |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Martín Sánchez C, Pérez Martín JM, Jin JS, Dávalos A, Zhang W, de la Peña G, Martínez-Botas J, Rodríguez-Acebes S, Suárez Y, Hazen MJ, Gómez-Coronado D, Busto R, Cheng YC, Lasunción MA: Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.,
Biochim Biophys Acta, 2015
PubMed |
| Value | 13.5 | Dimension | % |
| Error | Error not provided. |
| Relative compared to | control |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
| Sample source | cell line |
| CLO Cell line name | HL-60 cell (CLO:0003775) |
| Cell line/type as in publication | HL-60 acute promyelocytic cell line |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | LC-MS |
| Extraction method | acid extraction |
| Growth conditions | 24 hours incubation and treatment with 100 μM 6-Fluoromevalonate |
| Treatment | |
|---|---|
| Drug/stress type | drug |
| PubChem | 119214 |
| Applied drug | 6-Fluoromevalonate |
| Treatment details/effects | 6-Fluoromevalonate is a competitive inhibitor of mevalonate diphosphate decarboxylase |
| Genes and Proteins | |
|---|---|
| No genes or proteins manipulated. | |