2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001252
Members of this Pool
Members of control pools
POOL001251
Last modified: 10/Sep/2021
Results
Publication
Hofmann H, Logue EC, Bloch N, Daddacha W, Polsky SB, Schultz ML, Kim B, Landau NR: The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus., J Virol, 2012

PubMed PMCID
Value 0.0612
Dimension pmol/106 cell
Error (unspecified) 0.008
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source cell line
CLO Cell line name U-937 cell (CLO:0009465)
Cell line/type as in publication U937 cells
Compartment whole cell
Experiment Details
Measurement type dNTP incorporation assay
Extraction method methanol
Remarks to measurement type Diamond et al. 2004., single-nucleotide extension assay
Growth conditions cells were differentiated with phorbol myristic acid (PMA) for 20 h
Treatment
Treatment details/effects perturbation of the dNTP pool by dNTP triphosphohydrolase
Genes and Proteins
Gene name SAMHD1
Gene identifier 25939
Protein name SAMHD1
Protein identifier Q9Y3Z3
Genetic manipulation/variation extrachromosomal protein expression