DNTP004825
dTTP
dNTP Pool | |
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Pool identifier | POOL001215 |
Members of this Pool |
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Members of control pools |
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POOL001211 |
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Last modified: 10/Sep/2021
Results | |
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Publication |
Roy B, Guittet O, Beuneu C, Lemaire G, Lepoivre M: Depletion of deoxyribonucleoside triphosphate pools in tumor cells by nitric oxide.,
Free Radic Biol Med, 2004
PubMed |
Value | 88 | Dimension | % |
Error (standard deviation) | 5 |
Relative compared to | control |
Data presentation in publication | numerical |
Source | |
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Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
Sample source | cell line |
Tissue type | T4-lymphoblastoid cells |
Cell line/type as in publication | CEM-SS |
Compartment | whole cell |
Experiment Details | |
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Measurement type | dNTP incorporation assay |
Extraction method | methanol |
Growth conditions | cocultured for 16 h with activated macrophages at a 1:1 ratio with the NOS inhibitor, aminoguanidine and with nucleoside transporter inhibitor dipyridamole |
Treatment | |
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Drug/stress type | drug |
PubChem | 164944 , 3108 |
Applied drug | aminoguanidine, dipyridamole |
Treatment details/effects | physiological amounts of NO; dipyridamole: salvage pathway inhibitor; aminoguanidine: NOS inhibitor |
Genes and Proteins | |
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Gene name | nos2 |
Gene identifier | 4843 |
Protein name | Nitric oxide synthase, inducible |
Protein identifier | P35228 |
Genetic manipulation/variation | extrachromosomal protein expression |