2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL001187
Members of this Pool
Members of control pools
POOL001180
Last modified: 10/Sep/2021
Results
Publication
Roy B, Guittet O, Beuneu C, Lemaire G, Lepoivre M: Depletion of deoxyribonucleoside triphosphate pools in tumor cells by nitric oxide., Free Radic Biol Med, 2004

PubMed
Value 104.0997
Dimension %
Error Error not provided.
Relative compared to control
Data presentation in publication diagram
Source
Source organism mouse (Mus musculus)
Taxonomy 10090
Sample source cell line
Tissue type murine lymphoblastic leukemia
CLO Cell line name L-1210 cell (CLO:0007155)
Cell line/type as in publication L1210 lymphocytic leukemia cells
Compartment whole cell
Experiment Details
Measurement type dNTP incorporation assay
Extraction method methanol
Growth conditions cocultivated with macrophages previously stimulated by IFN-g/LPS for induction of iNOS expression for 4h in the presence of dipyridamole. Following that cells were removed from the macrophage monolayer and cultivated in fresh medium for 60 min.
Treatment
Drug/stress type drug
PubChem 3108
Applied drug dipyridamole
Treatment details/effects physiological amounts of NO; dipyridamole: salvage pathway inhibitor
Genes and Proteins
Gene name nos2
Gene identifier 4843
Protein name Nitric oxide synthase, inducible
Protein identifier P35228
Genetic manipulation/variation extrachromosomal protein expression