Results
Publication	Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH: High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells., Cell Metab, 2019 PubMed
Value	0.2518
Dimension	fold change
Error (standard deviation)	0.0989
Relative compared to	control
Data presentation in publication	diagram

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Tissue type	mammary epithelial cells
CLO Cell line name	MCF 10A cell (CLO:0007599)
Cell line/type as in publication	MCF10A
Compartment	whole cell

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	Ferraro
Growth conditions	3-day culture with 22 mM of glucose.

Treatment
Drug/stress type	drug
PubChem	5793
Applied drug	Glucose
Treatment details/effects	the reductionof PFK activity that alters the glucose metabolic pathway contributes to the high-glucose-induced effects in pancreatic cells

Genes and Proteins
Gene name	PFKL
Gene identifier	5211
Protein name	ATP-dependent 6-phosphofructokinase, liver type
Protein identifier	P17858
Genetic manipulation/variation	silencing