Results
Publication	Thientosapol ES, Bosnjak D, Durack T, Stevanovski I, van Geldermalsen M, Holst J, Jahan Z, Shepard C, Weninger W, Kim B, Brink R, Jolly CJ: SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation., Proc Natl Acad Sci U S A, 2018 PubMed PMCID
Value	17.1527
Dimension	fold change
Error (unspecified)	9.7948
Relative compared to	control
Data presentation in publication	diagram

Source
Source organism	mouse (Mus musculus) Taxonomy 10090
Animal strain	C57BL/6 mice
Sample source	tissue
Tissue type	splenocytes
Cell line/type as in publication	C57BL/6; Samhd1 Δ25/Δ25
Compartment	whole cell

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	with HIV-1 reverse transcriptase
Growth conditions	splenocytes were activated with 20 μg/mL S. typhosa LPS plus 20 ng/mL mouse IL-4 for 24 h; dNTPs were extracted from live cells 2 days after activation

Treatment
Drug/stress type	drug
Applied drug	LPS, IL-4

Genes and Proteins
Gene name	SAMHD1
Gene identifier	56045
Protein name	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Protein identifier	Q60710
Genetic manipulation/variation	mutation
Mutation in protein	25-bp frame-shift deletions within Exon 1, homozygous mutation