DNTP003976
dATP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL000999 |
| Members of this Pool |
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| Members of control pools |
|---|
| POOL000998 |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Thientosapol ES, Bosnjak D, Durack T, Stevanovski I, van Geldermalsen M, Holst J, Jahan Z, Shepard C, Weninger W, Kim B, Brink R, Jolly CJ: SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.,
Proc Natl Acad Sci U S A, 2018
PubMed PMCID |
| Value | 1.5147 | Dimension | pmol/106 cell |
| Error (unspecified) | 0.3146 |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
mouse
(Mus musculus)
Taxonomy 10090 |
| Animal strain | C57BL/6 mice |
| Sample source | tissue |
| Tissue type | splenocytes |
| Cell line/type as in publication | C57BL/6; Samhd1 Δ25/Δ25 |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | methanol |
| Remarks to measurement type | with HIV-1 reverse transcriptase |
| Growth conditions | resting Samhd1 Δ25/Δ25 cells |
| Treatment |
|---|
| Genes and Proteins | |
|---|---|
| Gene name | SAMHD1 |
| Gene identifier | 56045 |
| Protein name | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
| Protein identifier | Q60710 |
| Genetic manipulation/variation | mutation |
| Mutation in protein | 25-bp frame-shift deletions within Exon 1, homozygous mutation |