2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000953
Members of this Pool
Members of control pools
POOL000951 POOL000952
Last modified: 10/Sep/2021
Results
Publication
Cámara Y, González-Vioque E, Scarpelli M, Torres-Torronteras J, Caballero A, Hirano M, Martí R: Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome., Hum Mol Genet, 2014

PubMed PMCID
Value 0.3901
Dimension pmol/mg protein
Error (upper interquartile range) 0.5912
Data presentation in publication diagram
Source
Source organism mouse (Mus musculus)
Taxonomy 10090
Animal strain Tymp−/−/Upp1−/− mice
Sample source tissue
Tissue type liver
Compartment mitochondrion
Experiment Details
Measurement type dNTP incorporation assay
Extraction method acid extraction
Remarks to measurement type Ferraro P et al. Nucleic Acids Res. 2010.
Growth conditions 100 mg/kg THU
Treatment
Drug/stress type drug
PubChem 29243
Applied drug tetrahydrouridine
Genes and Proteins
Gene name Tymp
Gene identifier 72962
Protein name thymidine phosphorylase
Protein identifier Q99N42
Genetic manipulation/variation mutation
Mutation in protein knockout
Gene name Upp1
Gene identifier 22271
Protein name uridine phosphorylase 1
Protein identifier P52624
Genetic manipulation/variation mutation
Mutation in protein knockout