2'-Deoxycytidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000939
Members of this Pool
Members of control pools
POOL000933 POOL000934 POOL000934
Last modified: 10/Sep/2021
Results
Publication
Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates., Nat Immunol, 2012

PubMed PMCID
Value 1.8533
Dimension nM
Error (unspecified) 0.0533
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source cell line
CLO Cell line name U-937 cell (CLO:0009465)
Cell line/type as in publication U937 cells
Compartment whole cell
Experiment Details
Measurement type dNTP incorporation assay
Extraction method methanol
Remarks to measurement type with HIV-1 reverse transcriptase
Growth conditions N/A
Treatment
Treatment details/effects human HD206-7AA SAMHD1 expressing vector
Genes and Proteins
Gene name SAMHD1
Gene identifier 25939
Protein name Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Protein identifier Q9Y3Z3
Genetic manipulation/variation extrachromosomal expression of mutant protein
Mutation in protein consensus histidine and aspartate residues mutated to alanine