DNTP003619
dATP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL000911 |
| Members of this Pool |
|
| Members of control pools |
|---|
| POOL000909 |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Daly MB, Roth ME, Bonnac L, Maldonado JO, Xie J, Clouser CL, Patterson SE, Kim B, Mansky LM: Dual anti-HIV mechanism of clofarabine.,
Retrovirology, 2016
PubMed PMCID |
| Value | 28.125 | Dimension | % |
| Error (standard deviation) | 12.5 |
| Relative compared to | control |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
| Sample source | primary cells |
| Cell line/type as in publication | CD4+ T cells |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | methanol |
| Remarks to measurement type | with HIV-1 reverse transcriptase |
| Growth conditions | activated with 5 μg/ml phytohemagglutinin; 300 nM clofarabine |
| Treatment | |
|---|---|
| Drug/stress type | drug |
| PubChem | 119182 , N/A |
| Applied drug | clofarabine, phytohemagglutinin |
| Treatment details/effects | Ribonucleotide reductase (RNR) inhibitor; activation of leukocytes |
| Genes and Proteins | |
|---|---|
| No genes or proteins manipulated. | |