DNTP003530
dUTP
| dNTP Pool | |
|---|---|
| Pool identifier | POOL000886 |
| Members of this Pool |
|
| Members of control pools |
|---|
| POOL000883 |
|
Last modified: 10/Sep/2021
| Results | |
|---|---|
| Publication |
Pérez-Moreno G, Sánchez-Carrasco P, Ruiz-Pérez LM, Johansson NG, Müller S, Baragaña B, Hampton SE, Gilbert IH, Kaiser M, Sarkar S, Pandurangan T, Kumar V, González-Pacanowska D: Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.,
Malar J, 2019
PubMed PMCID |
| Value | 0.087 | Dimension | pmol/108 cell |
| Error (standard error) | 0.1217 |
| Data presentation in publication | diagram |
| Source | |
|---|---|
| Source organism |
malaria parasite
(Plasmodium falciparum)
Taxonomy 5833 |
| Sample source | strain |
| Cell line/type as in publication | 3D7 cloned line derived from isolate NF54 |
| Compartment | whole cell |
| Experiment Details | |
|---|---|
| Measurement type | dNTP incorporation assay |
| Extraction method | methanol |
| Remarks to measurement type | modified Horowitz |
| Growth conditions | 20 h incubation; IC50 |
| Treatment | |
|---|---|
| Drug/stress type | drug |
| Applied drug | Ethyl-4-(3-(4-(2,4-dioxo-3,4-dihydropyrimin-1(2H)-yl)-2-((tritylamino)methyl)butyl)uredio)benzoate |
| Treatment details/effects | dUTPase inhibition |
| Genes and Proteins | |
|---|---|
| No genes or proteins manipulated. | |