2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000826
Members of this Pool
Members of control pools
POOL000818
Last modified: 10/Sep/2021
Results
Publication
Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou J, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K, Brown GW: Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype., EMBO J, 2012

PubMed PMCID
Value 0.3659
Dimension dNTP/NTP * 1000
Error Error not provided.
Relative compared to NTP
Data presentation in publication diagram
Source
Source organism baker's yeast (Saccharomyces cerevisiae)
Taxonomy 4932
Bacterial or fungal strain pol30^f
Sample source strain
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions logarithmically growing cells were arrested in G1 with alpha factor (α) and released into 0.2 M HU; 150 min
Treatment
Drug/stress type drug
PubChem 3657
Applied drug hydroxyurea
Treatment details/effects Ribonucleotide reductase (RNR) inhibitor
Genes and Proteins
Gene name POL30
Gene identifier 852385
Protein name Proliferating cell nuclear antigen, PCNA
Protein identifier P15873
Genetic manipulation/variation mutation
Mutation in protein C-terminally Flag-tagged PCNA, reduced protein levels