2'-Deoxycytidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000550
Members of this Pool
Members of control pools
POOL000548
Last modified: 10/Sep/2021
Results
Publication
Rentoft M, Lindell K, Tran P, Chabes AL, Buckland RJ, Watt DL, Marjavaara L, Nilsson AK, Melin B, Trygg J, Johansson E, Chabes A: Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance., Proc Natl Acad Sci U S A, 2016

PubMed PMCID
Value 6.7669
Dimension fold change
Error (unspecified) 0.4
Relative compared to total NTP pool in untreated HCT116 cells
Data presentation in publication diagram
Source
Source organism human (Homo sapiens)
Taxonomy 9606
Sample source cell line
CLO Cell line name HCT 116 cell (CLO:0003665)
Cell line/type as in publication HCT116
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Remarks to measurement type Chabes
Growth conditions HCT116 cells incubated in the presence of 50 μM thymidine and 20 μM deoxyadenosine for 20 h, after which an additional 50 μM thymidine and 20 μM were added. dNTP pools were measured after 1 h
Treatment
Drug/stress type drug
PubChem 13730 , 5789
Applied drug deoxyadenosine, thymidine
Genes and Proteins
No genes or proteins manipulated.