Results
Publication	Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P: dNTP pools determine fork progression and origin usage under replication stress., EMBO J, 2012 PubMed PMCID
Value	337.54
Dimension	pmol/108 cell
Error	Error not provided.
Data presentation in publication	diagram

Source
Source organism	baker's yeast (Saccharomyces cerevisiae) Taxonomy 4932
Bacterial or fungal strain	pGAL-RNR1 (W1588-4C derivative)
Sample source	strain
Compartment	whole cell

Experiment Details
Measurement type	HPLC-UV
Extraction method	acid extraction
Growth conditions	Exponentially growing pGAL-RNR1 cells were cultured for 2 hours with 2% galactose before addition of 100 mM hydroxyurea for 60 min

Treatment
Drug/stress type	drug
PubChem	3657
Applied drug	hydroxyurea
Treatment details/effects	overexpression of Ribonucleoside-diphosphate reductase large chain 1, responsible for deoxynucleotide synthesis; inhibition of deoxynuclotide synthesis by hydroxyurea

Genes and Proteins
Gene name	RNR1
Gene identifier	856801
Protein name	Ribonucleoside-diphosphate reductase large chain 1
Protein identifier	P21524
Genetic manipulation/variation	extrachromosomal protein expression