2'-Deoxyguanosine-5'-triphosphate (Pubchem)
dNTP Pool
This entry does not belong to any pool in the database.
Members of control pools
POOL000217
Last modified: 10/Sep/2021
Results
Publication
Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P: dNTP pools determine fork progression and origin usage under replication stress., EMBO J, 2012

PubMed PMCID
Value 1.01
Dimension fold change
Error Error not provided.
Relative compared to control
Data presentation in publication diagram
Source
Source organism baker's yeast (Saccharomyces cerevisiae)
Taxonomy 4932
Bacterial or fungal strain ctf18∆ dun1∆ (W303 derivative)
Sample source strain
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions YEP medium supplemented with glucose or galactose; cells were synchronized in G1 by adding α-factor for 170 min
Treatment
Drug/stress type drug
PubChem 22461951
Applied drug α-factor
Treatment details/effects synchronization of cells in G1; mutation(s) in DNA damage response protein kinase DUN1, involved in DNA demage checkpoint (DDC) pathway, and in Chromosome transmission fidelity protein 18, involved in the DNA replication checkpoint (DRC) pathway
Genes and Proteins
Gene name DUN1
Gene identifier 851457
Protein name DNA damage response protein kinase DUN1
Protein identifier P39009
Genetic manipulation/variation mutation
Mutation in protein deletion
Gene name CTF18
Gene identifier 855102
Protein name Chromosome transmission fidelity protein 18
Protein identifier P49956
Genetic manipulation/variation mutation
Mutation in protein deletion