Results
Publication	Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P: dNTP pools determine fork progression and origin usage under replication stress., EMBO J, 2012 PubMed PMCID
Value	0.54
Dimension	fold change
Error	Error not provided.
Relative compared to	control
Data presentation in publication	diagram

Source
Source organism	baker's yeast (Saccharomyces cerevisiae) Taxonomy 4932
Bacterial or fungal strain	ctf4∆ dun1∆ (W303 derivative)
Sample source	strain
Compartment	whole cell

Experiment Details
Measurement type	HPLC-UV
Extraction method	acid extraction
Growth conditions	YEP medium supplemented with glucose or galactose; cells were synchronized in G1 by adding α-factor for 170 min ; then cells were released into YPD with 200 mM hydroxyurea for 60 min

Treatment
Drug/stress type	drug
PubChem	22461951 , 3657
Applied drug	α-factor, hydroxyurea
Treatment details/effects	synchronization of cells in G1, then cells were treated with hydroxyurea, which inhibits deoxynuclotide synthesis; mutation(s) in DNA damage response protein kinase DUN1, involved in DNA demage checkpoint (DDC) pathway, and in DNA polymerase alpha-binding protein, involved in maintaining replication fork integrity

Genes and Proteins
Gene name	DUN1
Gene identifier	851457
Protein name	DNA damage response protein kinase DUN1
Protein identifier	P39009
Genetic manipulation/variation	mutation
Mutation in protein	deletion
Gene name	CTF4
Gene identifier	856254
Protein name	DNA polymerase alpha-binding protein
Protein identifier	Q01454
Genetic manipulation/variation	mutation
Mutation in protein	deletion