2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000230
Members of this Pool
Members of control pools
POOL000217
Last modified: 10/Sep/2021
Results
Publication
Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P: dNTP pools determine fork progression and origin usage under replication stress., EMBO J, 2012

PubMed PMCID
Value 277.15
Dimension pmol/108 cell
Error Error not provided.
Data presentation in publication diagram
Source
Source organism baker's yeast (Saccharomyces cerevisiae)
Taxonomy 4932
Bacterial or fungal strain mec1-1 sml1-1 (W303 derivative)
Sample source strain
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions YEP medium supplemented with glucose or galactose; cells were synchronized in G1 by adding α-factor for 170 min
Treatment
Drug/stress type drug
PubChem 22461951
Applied drug α-factor
Treatment details/effects synchronization of cells in G1; mutation(s) in Serine/threonine-protein kinase MEC1 and Ribonucleotide reductase inhibitor protein SML1, involved in S-phase checkpoint
Genes and Proteins
Gene name MEC1
Gene identifier 852433
Protein name Serine/threonine-protein kinase MEC1
Protein identifier P38111
Genetic manipulation/variation mutation
Mutation in protein mec1-1 mutant
Gene name SML1
Gene identifier 854945
Protein name Ribonucleotide reductase inhibitor protein SML1
Protein identifier Q04964
Genetic manipulation/variation mutation
Mutation in protein sml1-1 mutant (region deletion)