2'-Deoxyadenosine 5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000218
Members of this Pool
Members of control pools
POOL000217
Last modified: 10/Sep/2021
Results
Publication
Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P: dNTP pools determine fork progression and origin usage under replication stress., EMBO J, 2012

PubMed PMCID
Value 59.93
Dimension pmol/108 cell
Error Error not provided.
Data presentation in publication diagram
Source
Source organism baker's yeast (Saccharomyces cerevisiae)
Taxonomy 4932
Bacterial or fungal strain mrc1AQ (W303 derivative)
Sample source strain
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions YEP medium supplemented with glucose or galactose; cells were synchronized in G1 by adding α-factor for 170 min
Treatment
Drug/stress type drug
PubChem 22461951
Applied drug α-factor
Treatment details/effects synchronization of cells in G1; mutations in Mediator of replication checkpoint protein 1, involved in the DNA replication checkpoint (DRC) pathway
Genes and Proteins
Gene name MRC1
Gene identifier 850297
Protein name Mediator of replication checkpoint protein 1
Protein identifier P25588
Genetic manipulation/variation mutation
Mutation in protein replication-checkpoint-defective mutant