Thymidine-5'-triphosphate (Pubchem)
dNTP Pool
Pool identifier POOL000135
Members of this Pool
Members of control pools
POOL000132
Last modified: 10/Sep/2021
Results
Publication
Schmidt TT, Reyes G, Gries K, Ceylan CÜ, Sharma S, Meurer M, Knop M, Chabes A, Hombauer H: Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis., Proc Natl Acad Sci U S A, 2017

PubMed PMCID
Value 149
Dimension pmol/108 CFU
Error (SD) 12
Data presentation in publication numerical
Source
Source organism baker's yeast (Saccharomyces cerevisiae)
Taxonomy 4932
Bacterial or fungal strain derivatives of the S288Cstrains RDKY3686
Sample source strain
Cell line/type as in publication pol3-L612M
Compartment whole cell
Experiment Details
Measurement type HPLC-UV
Extraction method acid extraction
Growth conditions N/A
Treatment
Treatment details/effects polimerase enzyme active site mutation
Genes and Proteins
Gene name pol3
Gene identifier 851456
Protein name DNA polymerase delta catalytic subunit
Protein identifier P15436
Genetic manipulation/variation mutation
Mutation in protein L612M