DNTP000430
dATP
dNTP Pool | |
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Pool identifier | POOL000108 |
Members of this Pool |
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Members of control pools |
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POOL000106 |
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Last modified: 10/Sep/2021
Results | |
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Publication |
Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA: Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.,
Cell Cycle, 2008
PubMed PMCID |
Value | 0.42 | Dimension | fold change |
Error (unspecified) | 0.03 |
Relative compared to | control |
Data presentation in publication | diagram |
Source | |
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Source organism |
human
(Homo sapiens)
Taxonomy 9606 |
Sample source | cell line |
Cell line/type as in publication | SK-Mel-19 |
Compartment | whole cell |
Experiment Details | |
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Measurement type | HPLC-UV |
Extraction method | acid extraction |
Remarks to measurement type | In the manuscript the authors use both, HPLC-UV and dNTP incorporation assay measurements, but it was not clear which of them has been applied to measure particular dNTP quantities. |
Growth conditions | N/A |
Treatment | |
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Treatment details/effects | IMPDH2-shRNA; Inosine-5'-monophosphate dehydrogenase 2 inhibition |
Genes and Proteins | |
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Gene name | IMPDH2 |
Gene identifier | 3615 |
Protein name | IMPDH2 |
Protein identifier | P12268 |
Genetic manipulation/variation | silencing |