Results
Publication	Franzolin E, Salata C, Bianchi V, Rampazzo C: The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase., J Biol Chem, 2015 PubMed PMCID
Value	0.485
Dimension	pmol/106 cell
Error (standard error)	0.103
Data presentation in publication	diagram

Source
Source organism	human (Homo sapiens) Taxonomy 9606
Sample source	cell line
Cell line/type as in publication	skin fibroblast derived from patient; DDGUOK heterozygous for two different mutations; i.e. K201fs214X; IVS4 splicing site
Compartment	mitochondrion

Experiment Details
Measurement type	dNTP incorporation assay
Extraction method	methanol
Remarks to measurement type	Ferraro
Growth conditions	DMEM with 4.5 g of glucose per liter; 10% (v/v) fetal calf serum; nonessential amino acids; and antibiotics

Treatment
Treatment details/effects	perturbation of deoxyguanosine metabolism

Genes and Proteins
Gene name	dguok
Gene identifier	1716
Protein name	DGUOK
Protein identifier	Q9BVK7
Genetic manipulation/variation	genetic variation
Mutation in protein	heterozygous for two different mutations, K201fs214X and IVS4 splicing site