dNTPpoolDB is the database of deoxyribonucleotide triphosphate (dNTP) content measured in biological samples. Stimulated by the growing interest in the role of the dNTP pool in physiological and malignant processes, dNTPpoolDB offers a comprehensive collection of dNTP data and pool reconstructions available from a wide range of species, experimental and developmental conditions. The database comprises quantitative data on the four canonical building blocks of DNA, dATP, dGTP, dCTP and dTTP, as well as exotic dNTPs also incorporated if available. dNTPpoolDB is manually curated, each entry is verified by a competent annotator.
The cellular concentration of DNA building blocks is maintained in homeostasis for proper DNA replication and repair. Mutagenesis is greatly stimulated by unbalanced dNTP pools, as well as by the balanced accumulation of all four dNTPs. The proportional depletion of dNTP pools causes genomic instability, as well, probably through replication stress. Accordingly, key roles of dNTP pool homeostasis have been demonstrated in cancer development, ageing and viral infections. dNTPpoolDB is designated to promote research in these fields and in the yet undiscovered aspects of dNTP pool homeostasis, comprising the potential signalling function of dNTP species.